Protective Role of Silymarin and Deferoxamine Against Iron Dextran-induced Renal Iron Deposition in Male Rats

نویسندگان

  • Mehdi Nematbakhsh
  • Zahra Pezeshki
  • Behjat Alsaadat Moaeidi
  • Fatemeh Eshraghi-Jazi
  • Ardeshir Talebi
  • Hamid Nasri
  • Shahrzad Baradaran
  • Marjan Gharagozloo
  • Tahereh Safari
  • Maryam Haghighi
چکیده

BACKGROUND Kidney iron deposition (KID) is caused by iron overload that is observed in kidney diseases and anemia. The protective effects of deferoxamine (DF) and silymarin (SM) were studied against iron overload-induced KID in rat model. METHODS Rats received iron dextran (200 mg/kg) for a period of 4 weeks every other day, but at the beginning of week 3, they also were subjected to a 2-week (every other day) treatment with vehicle (group 2, positive control), SM (200 mg/kg; group 3), DF (50 mg/kg; group 4), SM (400 mg/kg; group 5), and combination of SM and DF (200 and 50 mg/kg, respectively; group 6). Group 1, as the negative control, received saline alone during the study. The levels of serum creatinine (Cr), blood urea nitrogen (BUN), iron, ferritin, and nitrite were determined, and the kidney was removed for histopathological investigations. RESULTS Before treatment, the serum levels of iron and ferritin in all iron dextran receiver groups were significantly higher than those of the negative control group (P < 0.05). However, the serum levels of BUN, Cr, and nitrite were not different between the groups. No statistical differences were detected in kidney weight and the serum levels of BUN, Cr, iron, ferritin, and nitrite after 2 weeks of treatment with SM, DF, or combination of both. The SM and DF treatments reduced the intensity of the KID, but only in the SM (200 mg/kg) group, a significant reduction in KID was observed (P < 0.05). CONCLUSION It seems that SM is a nephroprotectant agent against KID in acute iron overload animal models.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Re: “Protective Role of Silymarin and Deferoxamine against Iron Dextran-Induced Renal Iron Deposition in Male Rats,” and “Co-Administration of Silymarin and Deferoxamine against Kidney, Liver and Heart Iron Deposition in Male Iron Overload Rat Model”

International Journal of Preventive Medicine, Vol 5, No 6, June, 2014 800 DEAR EDITOR, Recently, two articles entitled “Protective role of silymarin (SM) and deferoxamine (DF) against iron dextran‐induced renal iron deposition in male rats,” and “Co‐administration of SM and DF against kidney, liver, and heart iron deposition in male iron overload rat model” were published in International Journ...

متن کامل

Re: Protective Role of Silymarin and Deferoxamine against Iron Dextran - Induced Renal Iron Deposition in Male Rats

DEAR EDITOR, We read with respect the paper “Protective role of Silymarin and deferoxamine against iron dextran induced renal iron deposition in male rats by Nematbakhsh et al. It is an interesting paper; however, I would like to add some complementary comments to it. In this paper the Silymarin reduced the kidney iron deposition in an iron overload model. The findings have demonstrated that Si...

متن کامل

Comment on: The Protective Role of Silymarin and Deferoxamine Against Iron Dextran-Induced Renal Iron Deposition in Male Rats

DEAR EDITOR, The recently published an article by Nematbakhsh et al., entitled “Protective role of silymarin and deferoxamine against iron dextran‐induced renal iron deposition in male rats,” had some interesting point’s needs to explain more. They studied rats, which were allocated to six group and they received iron dextran for a period of 4 weeks every other day, but at the beginning of week...

متن کامل

Beyond the liver protective efficacy of silymarin; bright renoprotective effect on diabetic kidney disease

Diabetic nephropathy is one of the most important complications of diabetes mellitus (1). Recently much attention has been directed toward the use of silymarin in diabetic nephropathy (2). Silymarin possesses antioxidant and antiproteinuric effects in humans and in animal models (2,3). Silymarin seems to have two different effects in diabetic patients (2,3). Firstly control of blood sugar and s...

متن کامل

Co-Administration of Silymarin and Deferoxamine against Kidney, Liver and Heart Iron Deposition in Male Iron Overload Rat Model

BACKGROUND Tissue iron deposition may disturb functions of the organs. In many diseases like thalassemia, the patients suffer from iron deposition in kidney and heart tissues. Deferoxamine (DF) is a synthetic iron chelator and silymarin (SM) is an antioxidant and also a candidate for iron chelating. This study was designed to investigate the effect of DF and SM combination against kidney and he...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 4  شماره 

صفحات  -

تاریخ انتشار 2013